Basic Information
| First Name | |
| Last Name | |
| Organization | |
| Department | |
| Website | http://www.ohri.ca/profile/lacostelab |
Contact Information
| blacoste@uottawa.ca |
About My Research
Mouse Research Focus
Part of our lab studies neurodevelopmental disorders. For this, we use mouse models of the 16p11.2 deletion syndrome and of the Fragile X syndrome. We also have access to a Down syndrome mouse model through our collaboration with Dr. Brian Bennett (Queens U., Canada). The mouse models we use are the following: For 16p11.2 deletion syndrome: 16p11.2df/+ mice (Jackson Lab stock #013128; mixed B6/129 background). Heterozygous 16p11.2df/+ mice possess a microdeletion (~30 genes) in the 7qF3 region of synteny conservation with the human 16p11.2 locus. Hence, we can study haplodeficiency of any of these genes (the homozygous 16p11.2 deletion is embryonically lethal). For fragile X syndrome: Fmr1 KO mice (Jackson Lab stock #004624; mixed FVB/129 background). These mice harbor a knockout allele of Fmr1 gene located on the X chromosome, resulting in a lack of expression of the Fmr1 gene product. For Down syndrome: Dp(16)Yey/+ mice (Jackson stock #013530; mixed B6/129 background). These mice harbor trisomy of the Mmu16 region of synteny with human chromosome 21 (Hsa21) and carry 113 genes orthologous to genes on Hsa21.
| Gene ID | Symbol | Name | Tier | |
|---|---|---|---|---|
| 12721 | Coro1a | coronin, actin binding protein 1A | TIER2 | |
| 381921 | Taok2 | TAO kinase 2 | TIER2 | |
| 78388 | Mvp | major vault protein | TIER2 | |
| 68742 | Tmem219 | transmembrane protein 219 | TIER2 | |
| 17188 | Maz | MYC-associated zinc finger protein (purine-binding transcription factor) | TIER2 | |
| 21389 | Tbx6 | T-box 6 | TIER2 | |
| 26417 | Mapk3 | mitogen-activated protein kinase 3 | TIER2 | |
| 13446 | Doc2a | double C2, alpha | TIER2 | |
| 233877 | Kctd13 | potassium channel tetramerisation domain containing 13 | TIER2 | |
| 11674 | Aldoa | aldolase A, fructose-bisphosphate | TIER2 | |
| 14265 | Fmr1 | fragile X messenger ribonucleoprotein 1 | TIER2 | |
| 233876 | Hirip3 | HIRA interacting protein 3 | TIER2 | |
| 20737 | Spn | sialophorin | TIER2 | |
| 66090 | Ypel3 | yippee like 3 | TIER2 | |
| 110033 | Kif22 | kinesin family member 22 | TIER2 | |
| Term | Name | Aspect | Overlap | Size |
|---|