Rare Diseases: Models & Mechanisms Network

Profile

Wong, Judy

Basic Information

First Name
Last Name
Organization
Department
Website http://www.pharmacy.ubc.ca

Contact Information

Email judy.wong@ubc.ca
Phone 604-827-3314

About My Research

Human Cell Models Research Focus

Gene ID Symbol Name Tier
4931 NVL nuclear VCP like TIER3
54433 GAR1 GAR1 ribonucleoprotein TIER1
5981 RFC1 replication factor C subunit 1 TIER3
22925 PLA2R1 phospholipase A2 receptor 1 TIER3
6634 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide TIER3
6044 SNORA62 small nucleolar RNA, H/ACA box 62 TIER3
54984 PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 TIER3
55505 NOP10 NOP10 ribonucleoprotein TIER1
1111 CHEK1 checkpoint kinase 1 TIER3
3183 HNRNPC heterogeneous nuclear ribonucleoprotein C TIER3
4361 MRE11 MRE11 double strand break repair nuclease TIER3
7153 TOP2A DNA topoisomerase II alpha TIER2
6628 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 TIER3
7012 TERC telomerase RNA component TIER1
5591 PRKDC protein kinase, DNA-activated, catalytic subunit TIER2
4311 MME membrane metalloendopeptidase TIER3
3326 HSP90AB1 heat shock protein 90 alpha family class B member 1 TIER3
7014 TERF2 telomeric repeat binding factor 2 TIER3
55651 NHP2 NHP2 ribonucleoprotein TIER1
1026 CDKN1A cyclin dependent kinase inhibitor 1A TIER3
54386 TERF2IP TERF2 interacting protein TIER3
7155 TOP2B DNA topoisomerase II beta TIER2
10728 PTGES3 prostaglandin E synthase 3 TIER3
7157 TP53 tumor protein p53 TIER2
26821 SNORA74A small nucleolar RNA, H/ACA box 74A TIER3
80169 CTC1 CST telomere replication complex component 1 TIER3
1029 CDKN2A cyclin dependent kinase inhibitor 2A TIER3
55135 WRAP53 WD repeat containing antisense to TP53 TIER1
11200 CHEK2 checkpoint kinase 2 TIER3
3192 HNRNPU heterogeneous nuclear ribonucleoprotein U TIER3
3320 HSP90AA1 heat shock protein 90 alpha family class A member 1 TIER3
9221 NOLC1 nucleolar and coiled-body phosphoprotein 1 TIER3
55226 NAT10 N-acetyltransferase 10 TIER3
6635 SNRPE small nuclear ribonucleoprotein polypeptide E TIER3
9887 SMG7 SMG7 nonsense mediated mRNA decay factor TIER3
23293 SMG6 SMG6 nonsense mediated mRNA decay factor TIER3
545 ATR ATR checkpoint kinase TIER2
1736 DKC1 dyskerin pseudouridine synthase 1 TIER1
51384 WNT16 Wnt family member 16 TIER3
134353 LSM11 LSM11, U7 small nuclear RNA associated TIER3
25913 POT1 protection of telomeres 1 TIER3
472 ATM ATM serine/threonine kinase TIER2
7011 TEP1 telomerase associated protein 1 TIER3
23381 SMG5 SMG5 nonsense mediated mRNA decay factor TIER3
6117 RPA1 replication protein A1 TIER3
7013 TERF1 telomeric repeat binding factor 1 TIER3
5054 SERPINE1 serpin family E member 1 TIER3
10111 RAD50 RAD50 double strand break repair protein TIER3
6080 SNORA73A small nucleolar RNA, H/ACA box 73A TIER3
9894 TELO2 telomere maintenance 2 TIER3
54552 GNL3L G protein nucleolar 3 like TIER3
6043 SNORA63 small nucleolar RNA, H/ACA box 63 TIER3
85456 TNKS1BP1 tankyrase 1 binding protein 1 TIER3
7015 TERT telomerase reverse transcriptase TIER1
Term Name Aspect Overlap Size
GO:0003720 telomerase activity MF 3 7
GO:0005697 telomerase holoenzyme complex CC 7 22
GO:0007004 telomere maintenance via telomerase BP 7 24
GO:0072588 box H/ACA RNP complex CC 5 9
GO:0032203 telomere formation via telomerase BP 1 1
GO:0090399 replicative senescence BP 4 16

Publications

PubMed ID Title
26056849 Visualization of RNA-Quadruplexes in Live Cells.
30949698 Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in ...
27885969 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 ...
27956241 Real-time and quantitative fluorescent live-cell imaging with quadruplex-specific red-edge probe ...
23551398 Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.
21980366 Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences fo...
20837664 Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer...
16814507 Telomerase as a clinical target: current strategies and potential applications.
25893297 Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging...
29759988 Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics.
32003692 Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Releva...
31268434 Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belg...
27535322 Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopi...
30413703 Transcriptome-wide identification of transient RNA G-quadruplexes in human cells.
31383538 Diagnosis and Management of an Unusual Cyst 3 Years After Sacrocolpopexy.
27570172 Investigation of chromosome X inactivation and clinical phenotypes in female carriers of DKC1 mut...
23166583 In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase ...
21743490 Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-nega...
24115260 Severity of X-linked dyskeratosis congenita (DKCX) cellular defects is not directly related to dy...
32599885 Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners.
28862343 Cellular Detection of G-Quadruplexes by Optical Imaging Methods.
21258621 Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chro...
22058290 The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomer...
28872587 Quantification of Pseudouridine Levels in Cellular RNA Pools with a Modified HPLC-UV Assay.