Rare Diseases: Models & Mechanisms Network

Profile

Mallette, Frederick Antoine

Basic Information

First Name
Last Name
Organization
Department
Website https://crhmr.ciusss-estmtl.gouv.qc.ca/en/researcher/frederick-antoine-mallette

Contact Information

Email fa.mallette@umontreal.ca
Phone 514-252-3400 x3341

About My Research

Human Cell Models Research Focus

Epigenetics, gene expression, senescence, histone modifications, cellular transformation, cancer

Gene ID Symbol Name Tier
23411 SIRT1 sirtuin 1 TIER3
10459 MAD2L2 mitotic arrest deficient 2 like 2 TIER3
6775 STAT4 signal transducer and activator of transcription 4 TIER2
22925 PLA2R1 phospholipase A2 receptor 1 TIER3
23515 MORC3 MORC family CW-type zinc finger 3 TIER3
9869 SETDB1 SET domain bifurcated histone lysine methyltransferase 1 TIER2
8550 MAPKAPK5 MAPK activated protein kinase 5 TIER3
55611 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 TIER3
2475 MTOR mechanistic target of rapamycin kinase TIER1
51780 KDM3B lysine demethylase 3B TIER2
7404 UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked TIER3
5894 RAF1 Raf-1 proto-oncogene, serine/threonine kinase TIER2
7161 TP73 tumor protein p73 TIER3
6419 SETMAR SET domain and mariner transposase fusion gene TIER3
221037 JMJD1C jumonji domain containing 1C TIER2
2067 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit TIER3
8945 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase TIER2
7994 KAT6A lysine acetyltransferase 6A TIER3
3720 JARID2 jumonji and AT-rich interaction domain containing 2 TIER2
131870 NUDT16 nudix hydrolase 16 TIER3
7291 TWIST1 twist family bHLH transcription factor 1 TIER3
9891 NUAK1 NUAK family kinase 1 TIER3
596 BCL2 BCL2 apoptosis regulator TIER3
87178 PNPT1 polyribonucleotide nucleotidyltransferase 1 TIER3
983 CDK1 cyclin dependent kinase 1 TIER3
57178 ZMIZ1 zinc finger MIZ-type containing 1 TIER3
4311 MME membrane metalloendopeptidase TIER3
675 BRCA2 BRCA2 DNA repair associated TIER3
406 BMAL1 basic helix-loop-helix ARNT like 1 TIER3
1161 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit TIER3
29086 BABAM1 BRISC and BRCA1 A complex member 1 TIER3
84678 KDM2B lysine demethylase 2B TIER3
4862 NPAS2 neuronal PAS domain protein 2 TIER3
11335 CBX3 chromobox 3 TIER2
23636 NUP62 nucleoporin 62 TIER3
5604 MAP2K1 mitogen-activated protein kinase kinase 1 TIER3
23137 SMC5 structural maintenance of chromosomes 5 TIER3
3569 IL6 interleukin 6 TIER2
8242 KDM5C lysine demethylase 5C TIER3
5925 RB1 RB transcriptional corepressor 1 TIER2
9682 KDM4A lysine demethylase 4A TIER1
51147 ING4 inhibitor of growth family member 4 TIER3
23081 KDM4C lysine demethylase 4C TIER1
7014 TERF2 telomeric repeat binding factor 2 TIER2
10155 TRIM28 tripartite motif containing 28 TIER3
79697 RIOX1 ribosomal oxygenase 1 TIER3
11179 ZNF277 zinc finger protein 277 TIER3
23133 PHF8 PHD finger protein 8 TIER3
1026 CDKN1A cyclin dependent kinase inhibitor 1A TIER3
165918 RNF168 ring finger protein 168 TIER2
5582 PRKCG protein kinase C gamma TIER3
7157 TP53 tumor protein p53 TIER1
3265 HRAS HRas proto-oncogene, GTPase TIER3
10524 KAT5 lysine acetyltransferase 5 TIER3
84417 ECRG4 ECRG4 augurin precursor TIER3
3383 ICAM1 intercellular adhesion molecule 1 TIER3
79184 BRCC3 BRCA1/BRCA2-containing complex subunit 3 TIER3
6672 SP100 SP100 nuclear antigen TIER3
9306 SOCS6 suppressor of cytokine signaling 6 TIER2
632 BGLAP bone gamma-carboxyglutamate protein TIER3
4255 MGMT O-6-methylguanine-DNA methyltransferase TIER3
6776 STAT5A signal transducer and activator of transcription 5A TIER2
5253 PHF2 PHD finger protein 2 TIER3
27330 RPS6KA6 ribosomal protein S6 kinase A6 TIER3
8651 SOCS1 suppressor of cytokine signaling 1 TIER2
51384 WNT16 Wnt family member 16 TIER3
3014 H2AX H2A.X variant histone TIER3
79831 KDM8 lysine demethylase 8 TIER2
80317 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 TIER3
328 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 TIER3
545 ATR ATR checkpoint kinase TIER3
7023 TFAP4 transcription factor AP-4 TIER3
54929 TMEM161A transmembrane protein 161A TIER3
55693 KDM4D lysine demethylase 4D TIER1
23468 CBX5 chromobox 5 TIER2
28996 HIPK2 homeodomain interacting protein kinase 2 TIER3
4976 OPA1 OPA1 mitochondrial dynamin like GTPase TIER3
5054 SERPINE1 serpin family E member 1 TIER2
254225 RNF169 ring finger protein 169 TIER3
472 ATM ATM serine/threonine kinase TIER3
1956 EGFR epidermal growth factor receptor TIER3
140823 ROMO1 reactive oxygen species modulator 1 TIER3
23030 KDM4B lysine demethylase 4B TIER1
9093 DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 TIER3
2138 EYA1 EYA transcriptional coactivator and phosphatase 1 TIER3
554313 H4C15 H4 clustered histone 15 TIER3
3622 ING2 inhibitor of growth family member 2 TIER3
7015 TERT telomerase reverse transcriptase TIER3
6772 STAT1 signal transducer and activator of transcription 1 TIER2
2255 FGF10 fibroblast growth factor 10 TIER3
8091 HMGA2 high mobility group AT-hook 2 TIER3
7336 UBE2V2 ubiquitin conjugating enzyme E2 V2 TIER3
25989 ULK3 unc-51 like kinase 3 TIER3
80169 CTC1 CST telomere replication complex component 1 TIER3
10370 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 TIER3
26277 TINF2 TERF1 interacting nuclear factor 2 TIER2
9320 TRIP12 thyroid hormone receptor interactor 12 TIER3
390245 KDM4E lysine demethylase 4E TIER3
10075 HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 TIER2
9025 RNF8 ring finger protein 8 TIER2
100137047 JMJD7 jumonji domain containing 7 TIER2
6647 SOD1 superoxide dismutase 1 TIER3
10765 KDM5B lysine demethylase 5B TIER3
55010 PARPBP PARP1 binding protein TIER3
1054 CEBPG CCAAT enhancer binding protein gamma TIER3
811 CALR calreticulin TIER3
6777 STAT5B signal transducer and activator of transcription 5B TIER2
3987 LIMS1 LIM zinc finger domain containing 1 TIER3
8626 TP63 tumor protein p63 TIER3
672 BRCA1 BRCA1 DNA repair associated TIER3
221656 KDM1B lysine demethylase 1B TIER3
4282 MIF macrophage migration inhibitory factor TIER3
30837 SOCS7 suppressor of cytokine signaling 7 TIER2
387893 KMT5A lysine methyltransferase 5A TIER2
5549 PRELP proline and arginine rich end leucine rich repeat protein TIER3
55544 RBM38 RNA binding motif protein 38 TIER3
5371 PML PML nuclear body scaffold TIER1
9021 SOCS3 suppressor of cytokine signaling 3 TIER2
65094 JMJD4 jumonji domain containing 4 TIER2
1111 CHEK1 checkpoint kinase 1 TIER3
84142 ABRAXAS1 abraxas 1, BRCA1 A complex subunit TIER3
3159 HMGA1 high mobility group AT-hook 1 TIER3
80853 KDM7A lysine demethylase 7A TIER3
339123 JMJD8 jumonji domain containing 8 TIER2
23291 FBXW11 F-box and WD repeat domain containing 11 TIER2
10951 CBX1 chromobox 1 TIER2
1432 MAPK14 mitogen-activated protein kinase 14 TIER3
51366 UBR5 ubiquitin protein ligase E3 component n-recognin 5 TIER3
7320 UBE2B ubiquitin conjugating enzyme E2 B TIER3
50507 NOX4 NADPH oxidase 4 TIER3
4582 MUC1 mucin 1, cell surface associated TIER3
5580 PRKCD protein kinase C delta TIER3
55818 KDM3A lysine demethylase 3A TIER2
22992 KDM2A lysine demethylase 2A TIER3
2022 ENG endoglin TIER3
1154 CISH cytokine inducible SH2 containing protein TIER2
6773 STAT2 signal transducer and activator of transcription 2 TIER2
23135 KDM6B lysine demethylase 6B TIER2
8284 KDM5D lysine demethylase 5D TIER3
27250 PDCD4 programmed cell death 4 TIER3
6774 STAT3 signal transducer and activator of transcription 3 TIER2
51720 UIMC1 ubiquitin interaction motif containing 1 TIER3
23514 SPIDR scaffold protein involved in DNA repair TIER3
2140 EYA3 EYA transcriptional coactivator and phosphatase 3 TIER3
64798 DEPTOR DEP domain containing MTOR interacting protein TIER1
3064 HTT huntingtin TIER3
3576 CXCL8 C-X-C motif chemokine ligand 8 TIER2
3845 KRAS KRAS proto-oncogene, GTPase TIER2
122809 SOCS4 suppressor of cytokine signaling 4 TIER2
11200 CHEK2 checkpoint kinase 2 TIER3
23028 KDM1A lysine demethylase 1A TIER3
1029 CDKN2A cyclin dependent kinase inhibitor 2A TIER2
7403 KDM6A lysine demethylase 6A TIER3
4869 NPM1 nucleophosmin 1 TIER3
7468 NSD2 nuclear receptor binding SET domain protein 2 TIER2
6188 RPS3 ribosomal protein S3 TIER3
51230 PHF20 PHD finger protein 20 TIER2
253260 RICTOR RPTOR independent companion of MTOR complex 2 TIER1
3398 ID2 inhibitor of DNA binding 2 TIER3
6778 STAT6 signal transducer and activator of transcription 6 TIER2
22846 VASH1 vasohibin 1 TIER3
79677 SMC6 structural maintenance of chromosomes 6 TIER3
4335 MNT MAX network transcriptional repressor TIER3
673 BRAF B-Raf proto-oncogene, serine/threonine kinase TIER2
25913 POT1 protection of telomeres 1 TIER2
1021 CDK6 cyclin dependent kinase 6 TIER3
6909 TBX2 T-box transcription factor 2 TIER3
3299 HSF4 heat shock transcription factor 4 TIER3
286053 NSMCE2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase TIER3
7486 WRN WRN RecQ like helicase TIER3
7013 TERF1 telomeric repeat binding factor 1 TIER2
266740 MAGEA2B MAGE family member A2B TIER3
10783 NEK6 NIMA related kinase 6 TIER3
7334 UBE2N ubiquitin conjugating enzyme E2 N TIER3
23210 JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase TIER2
26013 L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 TIER2
9655 SOCS5 suppressor of cytokine signaling 5 TIER2
6926 TBX3 T-box transcription factor 3 TIER3
8835 SOCS2 suppressor of cytokine signaling 2 TIER2
2305 FOXM1 forkhead box M1 TIER3
10371 SEMA3A semaphorin 3A TIER2
3611 ILK integrin linked kinase TIER3
26156 RSL1D1 ribosomal L1 domain containing 1 TIER3
6722 SRF serum response factor TIER3
9577 BABAM2 BRISC and BRCA1 A complex member 2 TIER3
Term Name Aspect Overlap Size
GO:0045738 negative regulation of DNA repair BP 2 41
GO:0090400 stress-induced premature senescence BP 1 8
GO:2000772 regulation of cellular senescence BP 3 56
GO:0090402 oncogene-induced cell senescence BP 2 7
GO:2000774 positive regulation of cellular senescence BP 2 19
GO:0016577 obsolete histone demethylation BP 0 0
GO:0042772 DNA damage response, signal transduction resulting in transcription BP 0 1
GO:2000773 negative regulation of cellular senescence BP 1 26
GO:0007569 obsolete cell aging BP 0 0
GO:0045739 positive regulation of DNA repair BP 3 142
GO:0090398 cellular senescence BP 4 64

Roundworm Research Focus

Longevity, fertility, epigenetics

Gene ID Symbol Name Tier
182806 prmt-4 Methyltransferase domain-containing protein TIER2
179543 jmjd-5 Glucosamine 6-phosphate N-acetyltransferase;N-acetyltransferase domain-containing protein TIER2
184086 set-8 SET domain-containing protein TIER2
3565594 set-24 SPK domain-containing protein TIER2
182821 prmt-6 Methyltransferase domain-containing protein TIER1
181543 jmjd-3.2 JmjC domain-containing protein TIER2
175080 jmjd-2 Lysine-specific demethylase 4 TIER1
185242 set-11 SET domain-containing protein TIER2
180326 prmt-1 Protein arginine N-methyltransferase 1 TIER2
174425 set-17 Histone-lysine N-methyltransferase set-17 TIER2
177204 set-21 SET domain-containing protein TIER2
181467 jmjd-3.3 JmjC domain-containing protein TIER2
177232 jmjd-1.2 JmjC domain-containing protein;Lysine-specific demethylase 7 homolog TIER2
181111 jmjd-3.1 JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1 TIER2
171932 jmjc-1 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 TIER2
183391 set-32 SET domain-containing protein TIER2
189606 tor-2 Torsin TIER2
174045 set-4 Histone-lysine N-methyltransferase Suv4-20 TIER2
178221 prmt-9 PRotein arginine MethylTransferase TIER2
190641 set-28 SET domain-containing protein TIER2
176802 set-16 PHD-type domain-containing protein TIER2
353487 set-33 pseudo TIER2
172949 set-18 Histone-lysine N-methyltransferase set-18 TIER2
182356 set-3 SET domain-containing protein 3 TIER2
259530 jmjd-4 JmjC domain-containing protein TIER2
173626 set-13 SET domain-containing protein TIER2
185237 set-10 MYND-type domain-containing protein TIER2
181371 set-6 Histone-lysine N-methyltransferase set-6 TIER2
175717 prmt-5 Protein arginine N-methyltransferase 5 TIER2
179939 set-31 SET domain-containing protein TIER2
180835 set-20 SET domain-containing protein TIER2
176969 set-23 putative histone-lysine N-methyltransferase set-23 TIER2
180772 set-30 MYND-type domain-containing protein TIER2
172981 daf-16 Forkhead box protein O TIER2
187229 set-12 SET domain-containing protein TIER2
3565129 set-25 Histone-lysine N-methyltransferase set-25 TIER2
179457 set-22 SET domain-containing protein TIER2
190607 set-27 protein-histidine N-methyltransferase TIER2
179973 set-5 SET domain-containing protein;SPK domain-containing protein TIER2
178463 set-26 Histone-lysine N-methyltransferase set-26 TIER2
174812 jmjd-1.1 JmjC domain-containing protein TIER2
172727 prmt-7 Protein arginine N-methyltransferase 7 TIER2
189605 tor-1 Torsin TIER2
175662 set-2 Histone-lysine N-methyltransferase set-2 TIER2
175918 set-1 Histone-lysine N-methyltransferase set-1;SET domain-containing protein TIER2
187813 set-15 SET domain-containing protein TIER2
177196 set-9 Histone-lysine N-methyltransferase set-9 TIER2
174662 set-14 SET domain-containing protein 14 TIER2
180834 set-19 SET domain-containing protein TIER2
171705 set-29 SET domain-containing protein TIER2
176506 hpl-2 Chromobox protein homolog hpl-2 TIER1
Term Name Aspect Overlap Size