Rare Diseases: Models & Mechanisms Network

Profile

Langlais, David

Basic Information

First Name
Last Name
Organization
Department
Website https://www.langlaislab.com/

Contact Information

Email david.langlais@mcgill.ca
Phone 514-398-5844

About My Research

Mouse Research Focus

Working with genetically engineered mice for transcriptional regulators in the context of immune system development, response to infections and implication in the pathological inflammation

Gene ID Symbol Name Tier
22724 Zbtb7b zinc finger and BTB domain containing 7B TIER1
12394 Runx1 runt related transcription factor 1 TIER2
15900 Irf8 interferon regulatory factor 8 TIER1
320713 Mysm1 myb-like, SWIRM and MPN domains 1 TIER1
12609 Cebpd CCAAT/enhancer binding protein delta TIER1
18030 Nfil3 nuclear factor, interleukin 3, regulated TIER2
16362 Irf1 interferon regulatory factor 1 TIER1
104416 Bap1 Brca1 associated protein 1 TIER2
Term Name Aspect Overlap Size

Publications

PubMed ID Title
32344625 Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review.
33296702 Human T-bet Governs Innate and Innate-like Adaptive IFN-? Immunity against Mycobacteria.
27849203 Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinfl...
23754801 Adult pituitary cell maintenance: lineage-specific contribution of self-duplication.
30639577 USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-c...
22633955 The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcript...
24385922 Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs.
28760770 Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor re...
21193556 A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.
30127434 Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a d...
27001747 The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated...
25122610 Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8...
27974206 Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.
32641579 MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopo...
25710881 p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.
26791050 Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection.
27912315 Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Ex...
25473962 Specific dysregulation of IFN? production by natural killer cells confers susceptibility to viral...
26979842 Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.
26695862 The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease.
29922917 Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.
18927629 Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids a...
31827213 Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colore...
31792077 ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary ...
25403443 CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological ...
24105479 Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programmi...
21731497 Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and d...
23853600 Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
24973457 Genetic control of susceptibility to Candida albicans in SM/J mice.
27721430 USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.
26709616 Identification of Groundwater Nitrate Contamination from Explosives Used in Road Construction: Is...
29463745 Rocaglates as dual-targeting agents for experimental cerebral malaria.