Rare Diseases: Models & Mechanisms Network

Profile

Harris, Tony

Basic Information

First Name
Last Name
Organization
Department
Website http://csb.utoronto.ca/csb-faculty/tony-harris/

Contact Information

Email tony.harris@utoronto.ca
Phone 416-946-0873

About My Research

Fruit Fly Research Focus

We study the molecular bases of how animal cells and tissues are built. We use confocal and time-lapse microscopy in combination with Drosophila genetics and molecular biology to study how epithelial cells are formed and re-shaped during development. Epithelia are sheets of adherent cells that form boundaries between our body compartments. Each side of an epithelial sheet has distinct molecular properties. This epithelial polarity is critical for guiding embryo development and directing adult functions (e.g. nutrient uptake in the gut), and its loss is associated with cancer. We are focusing on the molecular machinery responsible for forming epithelial cells (polarity, adhesion, cytoskeletal and membrane trafficking complexes). We are identifying the proteins making up this machinery and determining how they function together in short-range and long-range circuits to establish, maintain and remodel epithelial structure in the Drosophila embryo.

Gene ID Symbol Name Tier
40506 Arf1 ADP ribosylation factor 1 TIER2
36054 egr eiger TIER3
34171 grk gurken TIER3
5656928 hup hold up TIER3
39881 TSG101 Tumor susceptibility gene 101 TIER3
37386 shg shotgun TIER2
34110 Rbsn-5 Rabenosyn-5 TIER3
36592 Shrm Shroom TIER3
31151 arm armadillo TIER2
41656 yrt yurt TIER3
32752 par-6 par-6 TIER2
34284 Pka-C1 Protein kinase, cAMP-dependent, catalytic subunit 1 TIER3
47396 mTor mechanistic Target of rapamycin TIER3
37356 sktl skittles TIER3
41673 Lkb1 Lkb1 kinase TIER3
35425 step steppke TIER1
32071 Kap3 Kinesin associated protein 3 TIER3
32544 Gbeta13F G protein beta subunit 13F TIER3
39643 sstn stepping stone TIER1
43700 spn-F spn-F TIER3
36059 14-3-3zeta 14-3-3zeta TIER3
35881 Ggamma1 G protein gamma subunit 1 TIER3
43904 AMPKalpha AMP-activated protein kinase alpha subunit TIER3
31646 Inx2 Innexin 2 TIER3
33156 l(2)gl lethal (2) giant larvae TIER3
36740 Zasp52 Z band alternatively spliced PDZ-motif protein 52 TIER3
34636 Rab6 Rab6 TIER3
42871 Apc2 Adenomatous polyposis coli 2 TIER3
33881 PDZ-GEF PDZ domain-containing guanine nucleotide exchange factor TIER3
41066 osk oskar TIER3
43331 btz barentsz TIER3
3355131 cta concertina TIER3
40489 mael maelstrom TIER3
2768852 par-1 par-1 TIER1
44086 DCTN2-p50 Dynactin 2, p50 subunit TIER3
38580 Dhc64C Dynein heavy chain 64C TIER3
33690 smog smog TIER3
317824 Zyx Zyxin TIER3
36775 Rho1 Rho1 TIER2
32777 Vps4 Vacuolar protein sorting 4 TIER3
31293 N Notch TIER3
32981 Cdc42 Cell division cycle 42 TIER3
37142 Sec6 Secretory 6 TIER3
36604 Sin1 SAPK-interacting protein 1 TIER3
47877 tws twins TIER3
42501 Rab11 Rab11 TIER3
40305 Pka-R1 Protein kinase, cAMP-dependent, regulatory subunit type 1 TIER3
45343 pk prickle TIER3
44861 sdt stardust TIER3
38418 kst karst TIER3
37355 insc inscuteable TIER3
35051 BicD Bicaudal D TIER3
40982 Sgt1 suppressor-of-G2-allele-of-skp1 TIER3
48571 heph hephaestus TIER3
42492 AnxB9 Annexin B9 TIER3
33619 ed echinoid TIER3
32083 dlg1 discs large 1 TIER3
37403 Magi magi TIER3
40679 Vha26 Vacuolar H[+]-ATPase 26kD subunit TIER3
33563 Sec5 Secretory 5 TIER3
43916 Rok Rho kinase TIER2
34179 dachs dachs TIER3
42896 crb crumbs TIER3
34405 lft lowfat TIER3
40553 Cont Contactin TIER3
39169 nudE nudE TIER3
44448 scrib scribble TIER3
37757 egl egalitarian TIER3
39536 DCTN1-p150 Dynactin 1, p150 subunit TIER3
32919 rictor rapamycin-insensitive companion of Tor TIER3
35505 scaf scarface TIER3
40517 alpha-Cat alpha Catenin TIER3
39063 PGRP-LC Peptidoglycan recognition protein LC TIER3
39332 Klp68D Kinesin-like protein at 68D TIER3
45233 capt capulet TIER3
43901 chb chromosome bows TIER3
42313 Delta delta TIER3
41302 Cad86C Cadherin 86C TIER3
35783 Asap ArfGAP with SH3 domain, ankyrin repeat and PH domain TIER1
45320 trol terribly reduced optic lobes TIER3
41788 jvl javelin-like TIER3
45307 fz frizzled TIER3
43528 Cad99C Cadherin 99C TIER3
37089 fj four-jointed TIER3
43003 veli veli TIER3
44071 Mcr Macroglobulin complement-related TIER3
44353 Shark SH2 ankyrin repeat kinase TIER3
35931 alc alicorn TIER3
36699 Arf6 ADP ribosylation factor 6 TIER2
33627 ft fat TIER3
31080 Tsp2A Tetraspanin 2A TIER3
33245 ds dachsous TIER3
32746 beta-Spec beta Spectrin TIER3
36773 Dg Dystroglycan TIER3
42743 cnc cap-n-collar TIER3
32703 baz bazooka TIER1
47594 aPKC atypical protein kinase C TIER1
35237 cyst cysts TIER2
32078 dsh dishevelled TIER3
41641 Elp6 Elongator complex protein 6 TIER3
41398 Csk C-terminal Src kinase TIER3
37402 mago mago nashi TIER3
35584 Eb1 Eb1 TIER3
37014 Dlish Dachs ligand with SH3s TIER3
31816 Moe Moesin TIER3
117332 Rheb Ras homolog enriched in brain TIER3
37244 Tbcb Tubulin-binding cofactor B TIER3
41952 msps mini spindles TIER3
36810 Khc Kinesin heavy chain TIER3
40620 cno canoe TIER3
38385 Girdin girdin TIER3
38021 p130CAS p130CAS TIER3
31239 egh egghead TIER3
42186 14-3-3epsilon 14-3-3epsilon TIER3
35847 Vps25 Vacuolar protein sorting 25 TIER3
38611 Klp64D Kinesin-like protein at 64D TIER3
50391 Grip Glutamate receptor interacting protein TIER3
33530 gkt glaikit TIER3
44642 Apc APC-like TIER3
33014 Rab35 Rab35 TIER3
33218 ex expanded TIER3
32537 Chc Clathrin heavy chain TIER3
44100 Patj patj TIER3
40191 kug kugelei TIER3
44855 rib ribbon TIER3
33409 Sec24CD Secretory 24CD TIER3
40694 Sec23 Secretory 23 TIER3
43163 Exo84 Exocyst 84 TIER3
41666 sqd squid TIER3
Term Name Aspect Overlap Size
GO:0035089 establishment of apical/basal cell polarity BP 2 8
GO:0005914 spot adherens junction CC 2 3
GO:0045176 apical protein localization BP 4 18
GO:0030011 maintenance of cell polarity BP 3 19
GO:0045186 zonula adherens assembly BP 5 9
GO:0005915 zonula adherens CC 3 8
GO:0016332 establishment or maintenance of polarity of embryonic epithelium BP 2 6
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity BP 5 27
GO:0030952 establishment or maintenance of cytoskeleton polarity BP 3 48
GO:0071896 protein localization to adherens junction BP 2 4
GO:0016327 apicolateral plasma membrane CC 1 22
GO:0035003 subapical complex CC 2 11

Publications

PubMed ID Title
16129788
12421828
20571587
15561583
22303000
22833561
19737642
24874871
19468069
24120639
22218888
12386930
24223978
22674065
20392741
15866026
23015757
24173807
15479740
11604403
17488624
18508861
24466078
11278598
22251558
20368978